The article compares the way COVID-19 has been managed in the East African Community and in the EU. How were the initial measures in each of the regions and what have been the consequences of the measures adopted, especially those related to confinement and vaccination. It discusses how the strength of European integration and the notable economic and technological development of its member states have provided a comparative advantage over the resources available to the East African Community. They conclude that, in addition to the undoubted importance of advancing in economic development, continuing to deepen regional cooperation in African territory would be an opportunity to better manage future threats.