Relationship between parental age and number of transmitted mutations.

(A) The number of mutations from 12 aye-aye trios assigned (“phased”) to either the female (blue) or male (red-orange) parent using the software package POOHA. The x-axis shows the age of each parent at conception, while the y-axis shows the number of inferred mutations phased for each parent. We performed a Poisson regression on the observed number of phased maternal and paternal mutations and scaled the prediction by the fraction of mutations phased to obtain the regression lines (Materials and methods). Shaded areas show 95% confidence intervals for the regression lines. (B) The number of mutations from 21 baboon trios assigned to each parent. (C) The number of mutations from 26 rhesus macaque trios assigned to each parent. Data come from Wang and colleagues [11] and Bergeron and colleagues [4]. (D) The number of mutations from 225 human trios assigned to each parent. Data come from Jónsson and colleagues [6]. The data underlying this figure can be found in S1 Data.