Postpartum depression (PPD) is a significant global maternal mental health issue often overlooked, particularly in Northern Nigeria, where the prevalence rate is 17.7% of mothers worldwide (LiuZarzuela et al., 2023; Carlson et al., 2024), and a total fertility rate of 7.5 in Northern Nigeria (NDHS, 2018), increasing vulnerability due to repeated childbirths at short intervals, creating physical and emotional strain. Little is known about how culturally relevant information sources and risk communication influence women’s knowledge and help-seeking behaviours in Niger State. The study seeks to address this gap in alignment with Sustainable Development Goals (SDGs) 3 and 17, which promote maternal well-being and global partnerships for health advancement. A mixed-methods design was adopted, comprising a survey (n = 384) and focus group discussions (FGD) (n = 32). Multistage and purposive sampling techniques were employed, and data were analysed using SmartPLS (Partial Least Squares), SPSS, and Yin’s thematic explanation model. Healthcare providers exerted the strongest influence on PPD knowledge (β = 0.71, p < .01). Social media and radio were other dominant sources of PPD knowledge, whereas family, friends, and television showed minimal influence on. Indigenous media, such as community radio and storytelling, also had a strong influence on knowledge about PPD. Strategic communication skills training emphasising risk communication, empathy, and culturally sensitive patient interaction for medical professionals, along with community-based risk messaging, and digital platforms integration, is recommended to improve knowledge about PPD, early help-seeking and reduce stigma.