SARS-CoV-2 Genome Variants Epidemiology Surveillance in Ethiopia and Targeted Mutational Changes of Structural S Spike Proteins Through Computational Analysis

Abstract Objective: This study aims to identify the variants of SARS CoV 2 that were circulating in Ethiopia and spot dynamic mutational changes of spike antigenicity based on genome data analysis to put forward preventative measurement against pandemic. Results: The genomes from Ethiopia were confirmed to be evolutionary related to RaTG13 and SL- bat coronavirus and Spike receptor sites were conserved. The clade distribution of the genome was reflected as GH, GR and other O and intended for new variants. 3 female samples were detected as variants of concern VUI202012/01GRY B.1.1.7 which Pango linage B.1.1.7 was originated from the UK. Despite 21 notable mutations, 71% D614G, 28% D614X, 35% N501Y and 21% NSP5 S284G mutation were occurred predominantly in our genome samples. and could be antigenicity and infectivity. Mutation on N440K was perceived in a sample and potency resist SER-52 antibody neutralization and vaccine escape.