This chapter interrogates the impacts of state violence and the proliferations of pro-separatist agitations in the Anglophone regions of Cameroon on vulnerable groups as its objective. Through secondary sources of data collection and content analysis, authors observed that the continued interplay of state violence and the various agitations for the independence of Ambazonia by separatist groups accounts for the ongoing displacement of women and children both as internally displaced persons and refugees. Hence, they argued that the unprecedented humanitarian challenges facing these vulnerable groups manifest in the various spheres of confrontations involving the Cameroonian security forces and various armed separatist groups in Southern Cameroon. Tables in this chapter provide links between how various dimensions of the Anglophone crisis affect women and children. This chapter discusses also the factors fuelling separatist agitations, future research directions, solutions and recommendations in resolving the Anglophone crisis in the Republique du la Cameroun.