The study sought to assess the relationship between digital financial inclusion, economic growth, inclusive business participation, income inequality and social protection expenditure on poverty reduction in Nigeria, Ghana, Kenya, Ethiopia and Rwanda between 1990 and 2025. The study used the Generalized Method of Moments (GMM) estimator and was based on the Inclusive Growth Theory and the Growth-Inequality-Poverty (GIP) framework. Their findings indicated that digital financial inclusion and economic growth positively and significantly affects poverty reduction, and that social protection expenditure has a significant negative effect. The participation of inclusive business and income inequality did not have significant impacts on poverty reduction. The study finds that a greater emphasis on digital financial inclusion and a continued economic expansion is essential to realize shared prosperity and decrease poverty in Sub-Saharan Africa. The study suggests better access to digital financial services, fostering inclusive growth policies, and better efficiency in the delivery of social protection programmes.