This study investigates the impact of transformer sizing and load variability on the generation of harmonics in the distribution network of the Federal University of Technology, Akure (FUTA), Nigeria. The analysis focuses on Total Harmonic Distortion Voltage (THDv) at various Points of Common Coupling (PCCs) connected to different transformer capacities. Results indicate that PCCs linked to 500 kVA transformers exhibit THDv values ranging from 0.9% to 21.05%, generally falling within acceptable limits, albeit with some outliers. In contrast, PCCs associated with 200 kVA transformers display a broader and more concerning THDv range, from 0.65% to 65%. Additionally, the study reveals a significant increase in THDv at night compared to daytime, attributed to the higher prevalence of non-linear loads during off-peak hours. These findings highlight the critical role of transformer sizing and load patterns in managing harmonic distortion, underscoring the need for effective power quality management strategies within university distribution networks.