Abstract It is common both crosslinguistically and specifically in Bantu languages for the prohibitive to be formed by a construction consisting of a cessative verb in collocation with a non-finite verb. This is also the case in Manda, an understudied Southern Tanzanian Bantu language. In Manda, a negative imperative is expressed by the auxiliary - kotok -, with the (lexical) meaning ‘leave (off), stop’, operating on an infinitive full verb. Intriguingly, there is variation in this construction, as - kotok - may be both formally reduced and may be used more broadly to denote non-factivity in other “non-main” (or non-standard) contexts. The aim of this study is to demonstrate that this functional and formal variation reflects a historical and ongoing process of grammaticalization along the verb-to-affix cline. Drawing on field data, the available historical data and (micro-)comparative data, this study argues that - kotok - is transforming into a more general non-main negation marker. These changes corroborate Güldemann’s hypothesis (Güldemann, Tom. 1999. The genesis of verbal negation in Bantu and its dependency on functional features of clause types. In Jean-Marie Hombert & Larry Hyman (eds.), Bantu historical linguistics, 545–587. Stanford, CA: CSLI Publications) that the salient category of non-standard secondary negative markers in Bantu is derived from constructions with an auxiliary and a non-finite verb.