The Lipstick Effect is traditionally used to describe the tendency of consumers to continue purchasing relatively affordable luxury goods during periods of economic uncertainty (Hill et al., 2012; MacDonald & Dildar, 2020). This paper proposes a contextual adaptation of this concept within the informal economy of West Africa, with particular attention to beauty entrepreneurship in Nigeria. Rather than examining the Lipstick Effect solely as a consumer response to financial hardship, the study explores whether the beauty sector can also function as a source of income generation and economic resilience for young entrepreneurs operating in an environment characterized by inflation, limited formal employment opportunities, and expanding digital commerce. An exploratory survey of 20 beauty entrepreneurs was used to examine four dimensions of the proposed framework: economic necessity as a motivation for entrepreneurship, continued demand for affordable beauty products and services, reliance on digital platforms as business channels, and perceptions of self-directed income compared with conventional employment. The original survey summary indicated strong agreement across these dimensions, including unanimous responses on economic necessity and digital storefront use and 95% agreement regarding continued consumer demand for affordable beauty products and services. Because of the small convenience sample and the absence of a recoverable respondent-level dataset, these findings are treated as preliminary descriptive evidence rather than statistically generalizable results. The paper proposes the concept of the West African Lipstick Effect Mutation, in which beauty entrepreneurship represents not only a response to consumer demand but also a potential economic adaptation to financial insecurity. The study contributes a preliminary conceptual framework linking consumer resilience, informal entrepreneurship, and digital commerce, while identifying the need for larger and more rigorous comparative studies.