This paper highlights the contribution of African and South American languages to theknowledge of the mechanisms of speech production and perception. It also reviews some of the dimensionsthat are involved in answering the questions raised by research on the structure and workingmechanisms of human speech. These questions are dealt with by examining the production and perceptionof clicks in Hadza and the nature of vowel systems in two South American languages, Karitianaand Nasa Yuwe. This paper is the extension of a presentation made at a meeting of the Section of Human Sciences held on9 February 2021. Text received on 3 January 2022 and submitted to peer review. Final version, approved by thereviewers, received on 18 January 2023. This contribution sums up and deals with more quantitative findingspresented in several publications mentioned in the text.