This is a comprehensive guide designed to enhance the research capacity of early and mid-career researchers in Sub-Saharan Africa. Focused on strengthening clinical trial regulatory and ethical review oversight in East Africa, the manual covers essential topics such as grant proposal development, project design, financial management, research ethics, and research leadership. It provides practical and theoretical training through lectures, group discussions, and exercises, aiming to equip participants with skills in grant writing, project management, and ethical research practices. The three-day training course, conducted in Uganda and Ethiopia, emphasizes strategic planning, stakeholder engagement, and mentorship to foster research ownership and leadership, ultimately aiming to increase research grants and credibility in the region.