WFE nexus is an important aspect in building sustainable economies. Water is used in food production while water supply and food processing require energy. Understanding the interrelationships of the nexus components is a growing interest for researchers and policymakers towards sustainable development. This chapter analyses the in-depth meaning of the WFE nexus, its importance, and its involved processes. The chapter also evaluates the effects of climate change on the nexus using case examples in South Africa. It also proposes a road map to facilitate better management of the nexus by recommending useful action plans. These action plans prioritize on baseline data collection, optimization of WFE nexus processes and cooperative management of resources, and climate change adaptation.