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Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis

Domain:

healthcare

Record type:

paper
Creator:
ShaLavHalFar
Publisher:
AOS
Host:
South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously.

Visit

doi.org

Licenses

https://creativecommons.org/licenses/by/4.0

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