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A consistent pattern of T2D PGR using SNPs and LRs from ethnic-specific studies.

Domaine:

healthcare

Type de record:

dataset
Créateur:
RonEriMarJoe
Hôte:avatar

The density plots were drawn for the histograms of log(PGR) values across 11 HapMap3 population groups using T2D SNPs and likelihood ratios (LRs) from previous studies specifically on each of the following ethnicities: Caucasian (A), African (B), Chinese (C), Japanese (D), and Indian Asian (E). Eleven HapMap3 population groups are plotted with solid or dashed lines with different colors. PGR presents Predicted Genetic Risk with higher risk on the right. A consistent pattern was observed with the highest PGR in the African populations (LWK, YRI, ASW, MKK) and the lowest PGR in the Asian populations (JPT, CHD, CHB) regardless which ethnic-specific T2D SNPs and LRs were used. p_Asi, p_Eur, and p_Afr represent the likelihoods of observing more extreme values of log(PGR, Asian)-log(PGR, Other), log(PGR, European)-log(PGR, others), and log(PGR, African)-log(PGR, Other) using randomly selected control genomic genotypes, respectively. All p values were calculated as two-sided p values. SNPs used in each figure are summarized in Table S4.

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Tags

GeneticsBiotechnologyBiological SciencesInformation and Computing SciencesMathematicst2dpgrsnpslrsethnic-specific

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