The aim of this framework document is to highlight these elements within the African context and provide some recommendations on how African countries can work on putting them in place by building on existing infrastructure. This will enable resource limited countries to start implementing appropriate genomics-based health-related interventions, drawing on experiences from elsewhere, but adapting to the African context where necessary. The document is written by volunteers, who are not necessarily experts in genomic or precision medicine but have a variety of data, science and clinical backgrounds. It is not aiming to be prescriptive or comprehensive, but rather to provide some information and recommendations to enable the implementation of genomic medicine. The document focuses on the clinical context, while indicating barriers to implementation (situational and needs), which includes additional research that is required for knowledge and evidence generation.