Abstract 18223: The Afro-DPP Program: A Pilot Cluster-Randomized Virtual Cardiometabolic Health Program to Improve Hypertension and Glycemic Control Among African Immigrants

Background: Black persons and immigrants in the US are disparately impacted by poor cardiometabolic health (CMH). We hypothesized that combining lifestyle intervention with culturally specific curriculum and remote monitoring will improve CMH. Aim: To test the effectiveness of a culturally tailored intervention on blood pressure (BP) and hemoglobin (Hb) A1ccontrol among African Immigrants. Methods: Afro-DPP is a pilot cluster-randomized trial (NCT05144737) that compared effectiveness of a multicomponent CMH intervention in 60 adults with ≥2 CMH risk factors attending two churches (first intervention or delayed intervention arms). First intervention arm began the lifestyle intervention with a Lifestyle Coach; delayed intervention arm began 6 months later. The outcomes were 6-month change in BP, body weight, and HbA1c. Results: There were 30 adults in each arm, mean age was 50.6(±11.9) years. At 6 months, in the first intervention arm, systolic BP and diastolic (BP decreased by 11.32 mmHg and 9.73 mmHg, respectively; in the delayed intervention arm SBP and DBP decreased by 9.31 mmHg and 5.34 mmHg, respectively ( Figure ). In the first and delayed intervention arms, we observed a 2.6kg and 2.4kg weight reduction, respectively. HbA1c reduction was greater in the first compared to delayed intervention arm (-0.29, 95% CI, -0.58 to 0.01%). Likelihood of BP (<130/80mmHg) and HbA1c (<7%) control were 2.00 (95% CI 1.73 to 2.29) and 1.57 (95% CI 1.02 to 2.42) times higher in the first compared to delayed intervention arm. Conclusions: The improvement in BP and body weight supports effectiveness of a culturally specific multicomponent intervention in improving CMH among African immigrants.