Anti-CD3+MK626 treatment rejuvenated pancreatic islets from new-onset diabetic NOD mice.

Confocal microscopy images of GLUT-2 (red) and insulin (green) staining of pancreatic sections from anti-CD3+MK626 treated mice. The box plots represent the percentage of GLUT-2+insulin- (right) and GLUT-2+insulin+ (left) pancreatic islets from mice treated with anti-CD3+placebo or anti-CD3+MK626 2 weeks after therapy stop as well as untreated new-onset and longstanding diabetic controls and are depicted with Tukey whiskers from minimum and maximum. Islets (at least 80) from each experimental group (5 to 7 mice) from 2 to 4 non-serial sections per mouse were examined. * vs. new-onset diabetic mice; † vs. longstanding diabetic mice; ‡ vs. age-matched normoglycemic NOD-scid mice. One symbol p<0.05; two symbols p<0.01.