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APOBEC3G expression and HIV-1 infection in Burkina Faso

Domaine:

healthcare
Créateur:
TegSerAbdDam
Éditeur:
AOS
Hôte:
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

Visit

doi.org

Licenses

https://creativecommons.org/licenses/by-nc/4.0

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