Lean Six Sigma (LSS) is a continuous improvement methodology that combines Six Sigma's data-driven approach to reducing process variation and defects with Lean's waste elimination principles. In order to improve academic and administrative service delivery, this study investigated the use of Lean Six Sigma in African tertiary institutions. Data was collected through interview of 22 persons (10 students, 6 academic staffs and 6 administrative staffs) and secondary data from previously published works on Lean, Six Sigma, and higher education management within Africa. The study used a descriptive research design. The Edu-DMAIC framework (Define, Measure, Analyze, Improve, and Control) and the seven principles of Lean systems were modified for educational settings and used to identify problems and provide long-term improvement methods. The preliminary investigations show that student performance and institutional productivity are adversely affected by issues like time waste in enrollment procedures, declining state of infrastructure, insufficient teaching resources, out-of-date curriculum delivery, and ineffective communication methods. This study developed a process workflow to improve teaching and learning delivery, expedite communication, cut down on delays, and digitize administrative procedures. Thereafter, the value expectations of important stakeholders, such as students, departments, teachers, and management was identified. Conclusively, implementing Lean Six Sigma can successfully improve operational effectiveness, raise student satisfaction, maximize resource use, and support long-term, high-quality education in tertiary institutions in Africa. It is recommended that African tertiary institutions implement Lean Six Sigma principles in all administrative and academic activities to promote continuous improvement and efficient service delivery.