This article explores the impact of Artificial Intelligence (AI) on the practice of conference interpreting in Cameroon. Using a mixed-methods approach, it combines a survey of 41 conference interpreters with in-depth follow-up interviews. Results reveal that 95.1% of respondents view AI knowledge as essential for conference interpreters, recognizing its potential to enhance efficiency, productivity, and accuracy. However, concerns about cultural nuances, data privacy, and quality persist. The study underscores the importance of equipping interpreters with skills to effectively use AI-powered tools, emphasizing the role of training programmes and lifelong learning. This research provides valuable insights into the opportunities and challenges AI presents for conference interpreting, offering guidance for practitioners, stakeholders, and professional associations.