The largest economy in Africa and the most populous country, Nigeria is experiencing its own challenges in the integration of artificial intelligence (AI) technologies into the social work practice. This paper discusses the integration of AI and human interaction into the Nigerian social work system, including the opportunities and associated challenges related to the socio-economic, cultural, and technological realities in Nigeria. This paper explores the potential of AI to supplement existing social work practices and enhance service delivery. By examining existing literature, ongoing trends and developments, as well as situational factors. This paper argues that even though AI holds substantial promise in overcoming the social service delivery challenges faced by Nigeria, including poor infrastructure, scarce resources, and local demand, the introduction of AI solutions should be culturally sensitive and culturally suitable. The practice of social work in Nigeria is based on the community models and infusion of AI should not compromise these models. The results indicate that Nigerian social workers should develop technological capacity and champion inclusive AI development that addresses the digital divide, language diversity, and solutions that are culturally sensitive. Furthermore, this paper also highlights the need to implement the Ubuntu philosophy which places special emphasis on communal values, empathy, and mutual respect, in order to make sure that the AI-based interventions are properly in line with the social welfare objectives of the country.