Waterleaf (Talinum triangulare) is one of the most important indigenous leafy vegetables cultivated in tropical Africa because of its rapid growth, high nutritional value, and economic importance. However, productivity and nutritional quality are often constrained by poor agronomic practices, particularly inappropriate plant spacing and inadequate soil fertility management. This study evaluated the effects of different plant spacing and organic manure rates on the growth, yield, and nutrient composition of waterleaf under field conditions.