This data is from a qualitative research that developed and refined contextually relevant 'Undetectable=Untransmittable' messages targeting couples in mixed HIV-status relationships in Malawi. In the study, we conducted iterative cognitive interviews - in two iterations - with 9 men and 10 women living in relationships with different HIV statuses recruited from four health centres in Blantyre district. Cognitive interviews were done with couples in mixed HIV-status relationships to review the materials that were already developed by professional communication experts.