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Best fit immune parameters from SGD calibration.

Domaine:

healthcare

Type de record:

paper
Créateur:
AgaRusPra
Hôte:avatar

Agent-based models of malaria transmission are useful tools for understanding disease dynamics and planning interventions, but they can be computationally intensive to calibrate. We present a multitask deep learning approach for emulating and calibrating a complex agent-based model of malaria transmission. Our neural network emulator was trained on a large suite of simulations from the EMOD malaria model, an agent-based model of malaria transmission dynamics, capturing relationships between immunological parameters and epidemiological outcomes such as age-stratified incidence and prevalence across eight sub-Saharan African study sites. We then use the trained emulator in conjunction with parameter estimation techniques to calibrate the underlying model to reference data. Taken together, this analysis shows the potential of machine learning-guided emulator design for complex scientific processes and their comparison to field data.

Visit

figshare.com

Tags

GeneticsNeuroscienceBiotechnologyCancerInfectious DiseasesBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedunderstanding disease dynamicsparameter estimation techniquesneural network emulator+24

Licenses

CC BY 4.0

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