Among the Luo of Kenya, blood carries potencies that make life. The common saying ‘blood follows blood’ embodies this flow of potencies between different entities (human and non-human) that creates life and changes life-courses. The materiality of blood is agentive here, in the sense that it produces diverse human conditions. Examples are given specifically from life-cycle rituals, prayers, and healing practices of a Luo community in western Kenya. Ultimately, the sentient agency of blood defines the essence and dimensions of life in this case. Our focus on the conditions and processes that make life is contrasted with culturalist approaches, which misrecognize life plurality.