Cerebral malaria (CM) is one of the most severe neurological sequelae of Plasmodium falciparum infection, and remains a leading cause of death and long-term neurological impairment in children and adults living in subSaharan Africa. Almost one-quarter of the world’s malaria infections and deaths occur in Nigeria, the country most affected by malaria globally. Rural communities suffer a disproportionate burden of illness and mortality due to poverty, poor healthcare infrastructure, delayed diagnosis, lack of skilled healthcare workers, poor transit systems, cultural beliefs and restricted access to effective antimalarial treatments. Over the past two decades, much progress has been made in malaria management, but cerebral malaria continues to be a major burden on health care delivery and nursing practice in resource-limited settings. The review critically appraises the epidemiology, pathophysiology, clinical symptoms, diagnosis, treatment, prevention and public health implications of cerebral malaria in rural Nigeria. Special attention is given to problems facing healthcare professionals and the critical role of nurses in mitigating illness burden through health education, early identification, emergency management, patient advocacy, community mobilisation, and implementation of evidence-based interventions. The analysis also highlights the socio-economic factors of disease outcome and provides pragmatic suggestions aimed at improving nursing practice, health delivery in rural areas and malaria elimination initiatives in Nigeria. Addressing these difficulties would involve collaboration among governments, healthcare professionals, researchers, community leaders and international partners to enhance access to excellent healthcare and reduce preventable fatalities from cerebral malaria.