Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal

International audience Class D OXA β-lactamases are characterized as penicillinases that can hydrolyze oxacillin and cloxacillin and are poorly inhibited by clavulanic acid and EDTA. OXA-48 is one of the few members of this family to possess notable carbapenem-hydrolyzing activity. First described in 2004 in Turkey, OXA-48 has recently started to spread in Europe and the Middle East. We report the recent emergence of the plasmid-encoded bla OXA-48 gene in multidrug-resistant Enterobacteriaceae recovered from patients in Dakar, Senegal, in hospitals and in the community.