Classification using the disease risk score on the test cohort and validation dataset.

Disease risk score and receiver operating characteristic curves based on the TB/LTBI 27 transcript signature (A/B) and the TB/OD 44 transcript signature (C/D) applied to the South African (SA)/Malawi HIV+/− test cohort (A/C) (n_TB = 37 n_LTBI = 39/n_TB = 42 n_OD = 34) and independent validation dataset comprising South African patients (B/D) (n_TB = 20 n_LTBI = 31 n_OD = 82). Sensitivity, specificity are reported in Table 3. HIV+, HIV-infected; HIV−, HIV-uninfected. Classification cut-offs: (A) 138.98; (B) 107.76; (C) 154.44; (D) 99.94.