This systematic review will evaluate clean cooking interventions in Africa, focusing on their effects on household air-pollution exposure, health outcomes, and adoption and sustained use. The review will synthesize quantitative evidence on pollutants such as PM₂.₅ and carbon monoxide and health outcomes including blood pressure, pneumonia, respiratory morbidity, and birth weight, alongside qualitative evidence on barriers and facilitators to sustained use. The expected outcomes are to determine the effectiveness of clean cooking interventions in reducing exposure and improving health, identify key factors influencing sustained adoption and fuel stacking, and highlight evidence gaps to inform future research, policy, and implementation of clean cooking programmes in Africa.