An 8- year- old white Arewa stallion was hospitalized in our facility (Veterinary Teaching Hospital, Ahmadu Bello University, Zaria) with the primary complaints of fleshy growth on the lower eyelid of the right eye and unilateral left scrotal enlargement. Biopsies were taken via fine needle aspirate from the growth and sent to the histopathology laboratory of the Department of Veterinary Pathology, Ahmadu Bello University Zaria. Histo-pathology results confirmed 3rd stage of squamous cell carcinoma (SCC). Treatment was instituted using vincristine sulphate at a dose rate of 0.025mg/kg and a cyclo-oxygenate 2 inhibitor, diclofenac sodium at a dose rate of 0.5mg/kg for 6 cycles. The surgery was shelved because of the outcome of the therapy. The tumour regressed and the scrotum returned to normal size. The patient recovered and was discharged 2 weeks after the 6 weeks of therapy. The clinical relevance of note is that the above cocktail might be employed in managing early stage of SCC therapy where surgery is not required.