Maize, scientifically known as Zea mays L., holds significant agricultural value worldwide, serving as a staple food source and industrial cereal. It is grown across diverse environmental settings to meet varying demands. Corn is susceptible to infestation by a range of insect pests, with the stem-boring lepidopterans posing a particularly severe threat and leading to substantial reductions in crop yield. The biodetrimental effects of different treatments (plant extracts and bio-agents) on the pink corn borer, Sesamia cretica was investigated. Based on the findings, it can be concluded that the compounds tested had a significant impact on the management of the pink corn borer, S. cretica. The outcomes indicate that treating corn hybrids with biological substances could be highly beneficial as part of an integrated pest management (IPM) strategy for corn crops in Egypt, aiming to prevent environmental contamination and potential risks to humans and animals, all while striving to enhance maize yield both in terms of quantity and quality through the implementation of a comprehensive pest control program targeting insects that infest maize fields.