Cross-reactive antibody target between VAR2CSA DBL5ε variants.

Cross-reactivity was determined by competition ELISA using either a multigravid plasma pool with high titer of VAR2CSA-specific antibodies (Beninese or Senegalese women), plasma from DBL5ε_CYK39 or CYK49 DNA genetic vaccinated mouse (A). NTS-DBL1α domain of VARO was used as negative control (B). Each colour shows the reactivity with the indicated antibodies.