Toponyms are integral to daily lexicon, functioning as designators for cities, towns, nations, and tiny villages. This study, therefore, delved into a morphosyntactic and semantic analysis of toponyms in the Nkomazi region, South Africa. This study employed structural and functional methodologies to analyse naming patterns, positing that African names can be classified into two morphosyntactic groups as an indication of language. Subsequently, twenty-five geographical designations and seven significant respondents from the area were chosen. The 25 place names underwent morphosyntactic analysis concerning their etymology and meanings, while semi-structured interviews were employed to gather information on these aspects from seven respondents, utilising the framework of frame semantic theory established by Charles Fillmore, which elucidates the connection between word meanings and comprehension of real-world states and concepts. It posits that words trigger or evoke “frames” of knowledge and experience, which are cognitive constructs representing common circumstances or experiences. The findings indicate that place names in the Nkomazi region are derived from grammatical norms resulting from linguistic alterations. These names are constructed from nouns and their corresponding phrases through a process known as derivational morphology. Furthermore, the study identifies three primary methods of naming: prefixation, compounding, and borrowing. The results demonstrate that place names in the Nkomazi region are both clear and descriptive in their purpose. Consequently, locations are analysed based on numerous factors, including topographical features, historical events, climatic conditions, and prominent individuals.