In July 2023, a diabetic from Mauritania was diagnosed as a severe case of Crimean-Congo hemorrhagic fever (CCHF) at Dakar hospital, Senegal. The phylogenetic analysis revealed the new strain as a CCHF virus reassortant between Genotype Ⅰ and Ⅲ, closely linked to strains from Spain, Mauritania, Senegal and South Africa. Genetic variability of the virus in West Africa underscores the urgent need for enhanced surveillance in West Africa.