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Development and validation of a prognostic score during tuberculosis treatment

Domaine:

healthcare

Type de record:

paper
Créateur:
PefAdaPokHad
Éditeur:
fig
Hôte:avatar
Abstract Background Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas. Methods We used data for patients aged ≥15 years, diagnosed and treated for tuberculosis at the Yaounde Jamot Hospital between January 2012 and December 2013. Baseline characteristics associated with mortality were investigated using logistic regressions. A simple prognosis score (CABI) was constructed with regression coefficients for predictors in the final model. Internal validation used bootstrap resampling procedures. Models discrimination was assessed using c-statistics and calibration assessed via calibration plots and the Hosmer and Lemeshwow (H-L) statistics. The optimal score was based on the Youden’s index. Results A total of 2250 patients (men 57.2%) with a mean age of 35.8 years were included; among whom 213 deaths (cumulative incidence 9.5%) were recorded. Clinical form of tuberculosis (C), age (A, years), adjusted body mass index (B, BMI, kg/m2) and status for HIV (Human immunodefiency virus) infection (I) were significant predictors in the final model (p 

Visit

doi.orgfigshare.com

Languages

Ewondo

Tags

MedicineBiotechnology59999 Environmental Sciences not elsewhere classifiedFOS: Earth and related environmental sciences69999 Biological Sciences not elsewhere classifiedFOS: Biological sciencesCancerScience Policy110309 Infectious DiseasesFOS: Health sciences

Licenses

CC BY 4.0https://creativecommons.org/licenses/by/4.0

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