This paper has explored disruptive innovation as a driving force in corporate entrepreneurship in Federal Medical Centres in southeast Nigeria. In particular, it examined how the digital health innovation, use of telemedicine, process innovation, and service delivery innovation affect innovativeness, proactiveness, risk-taking behaviour, and strategic renewal, respectively. A cross-sectional survey was performed, and the data of 300 healthcare workers of three Federal Medical Centres using a structured questionnaire was collected. The analysis of data was done by descriptive statistics and Pearson Product-Moment Correlation at the level of significance of 0.05 in SPSS. The analysis showed the strong and statistically significant positive correlation: digital health innovation and innovativeness (r = .953); telemedicine adoption and proactiveness (r = .900); process innovation and risk-taking behaviour (r = .895); and service delivery innovation and strategic renewal (r = .884). These findings indicate that disruptive innovation contributes greatly to the aspects of corporate entrepreneurship in the public healthcare facilities. Based on this, the study concludes that the adoption of digital technologies, innovative processes, and patient-centred service models enhances organisational flexibility, responsiveness, and long-term sustainability within Federal Medical Centres. It suggested further investments in the digital infrastructure, improved practice in telemedicine, institutionalisation of continued improvement in the process, and the introduction of new models of service delivery to foster the development and performance of the entrepreneurship in the publicly owned medical organisations.