The Population Council is the research partner to DREAMS—a global partnership to reduce HIV infections among adolescent girls and young women (AGYW) in 10 sub-Saharan African countries. DREAMS aims to reduce HIV infections among adolescent girls and young women. This dataset is Round 1 data collection with young Malawian women (aged 15–24 years) enrolled in DREAMS programming. These data are from a Population Council-led implementation science study to assess the reach and effectiveness of DREAMS programming in two catchment areas.