Logo Lanfrica
  • Accueil
  • Atlas
  • Analyses
  • Documentation
  • Sign in

© 2026 Lanfrica. Tous droits réservés. Tous les droits d'auteur des ressources affichées sur le site Web Lanfrica appartiennent aux détenteurs de droits d'auteur d'origine, sauf indication contraire explicite.

Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015

Domaine:

healthcare

Type de record:

paperdataset
Créateur:
GupMacBulSal
Éditeur:
InsUniBarCen
Éditeur:
CCSDCen
Hôte:avatar
International audience One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collected from 4 sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps polymorphisms and for plasmepsin2 (pfpm2) and pfmdr1 copy numbers. We found multiple copies of pfpm2 in 1.1% of isolates. All isolates carried K13 wild-type alleles (3D7-like), except 4 novel polymorphisms (Leu619Leu, Phe656Ile, Val666Val, Gly690Gly). Prevalence of isolates with pfcrt mutant (K76T) allele was low (2.3%). Prevalence of isolates with pfdhps mutant alleles (A437G and K540E) was >80%, indicating persistence of sulfadoxine/pyrimethamine resistance; however, markers of artemisinin were absent, and markers of piperaquine resistance were low. Piperaquine resistance isolates may spread in Mozambique as dihydroartemisinin/piperaquine drug pressure increases.

Visit

pasteur.hal.science

Tags

vector-borne infectionspolymorphismsplasmepsin2parasitesmalariacopy numberantimicrobial resistanceMozambiqueK13MESH: Alleles+10

Licenses

http://creativecommons.org/licenses/by/info:eu-repo/semantics/OpenAccess

Similaires

Artemisinin Resistance–Associated K13 Polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010–2015Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTsInteractions Between Antenatal Sulfadoxine-Pyrimethamine, Drug-Resistant Plasmodium falciparum Parasites, and Delivery Outcomes in MalawiDetection of antimalarial drug resistance polymorphisms in <i>Plasmodium falciparum</i> chloroquine resistance transporter and <i>Plasmodium falciparum</i> multidrug resistance 1 genes of <i>Plasmodium falciparum</i> found in Kano State, NigeriaNovel pfk13 polymorphisms in Plasmodium falciparum population in GhanaDrug resistance gene polymorphisms of Plasmodium falciparum clinical isolates from Kinshasa, Democratic Republic of the Congo

Artemisinin Resistance–Associated K13 Polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010–2015

Emerging artemisinin resistance is a threat to global malaria control. Mutations in the Plasmodium

Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

Interactions Between Antenatal Sulfadoxine-Pyrimethamine, Drug-Resistant Plasmodium falciparum Parasites, and Delivery Outcomes in Malawi

Abstract Background Sulfadoxine-pyrimethami

Detection of antimalarial drug resistance polymorphisms in <i>Plasmodium falciparum</i> chloroquine resistance transporter and <i>Plasmodium falciparum</i> multidrug resistance 1 genes of <i>Plasmodium falciparum</i> found in Kano State, Nigeria

Objectives: In 2018, malaria claimed an estimated 380,000 lives in African region, with Nigeria ac

Novel pfk13 polymorphisms in Plasmodium falciparum population in Ghana

Abstract The molecular determinants of Plasmodium falciparum artemisinin resistance are the singl

Drug resistance gene polymorphisms of Plasmodium falciparum clinical isolates from Kinshasa, Democratic Republic of the Congo

Abstract Background