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Early environmental determinants of child lung health in a South African birth cohort study. (HHEAR 2020-00652)

Domaine:

healthcare

Type de record:

dataset
Créateur:
HHE
Hôte:avatar
We propose to leverage a unique South African birth cohort, the Drakenstein Child Health Study (DCHS) to investigate the impact of early-life exposures on chronic respiratory disease in children, and potential mediating underlying inflammatory processes. We will utilise this well phenotyped cohort with longitudinal measures antenatally through childhood and the associated biorepository. We hypothesise that early life environmental exposures increase susceptibility to develop chronic respiratory disease in childhood, which is mediated by systemic inflammation. Specific hypotheses: Hypothesis 1: Early-life environmental exposures to polycyclic aromatic hydrocarbons (PAHs), phenols, or pesticides are associated with chronic respiratory disease in children. Hypothesis 2: Early-life environmental exposures are associated with systemic inflammation, which mediates impairment in respiratory health. Preservation mirror of HHEAR study 2020-00652 from the HHEAR Data Center (hheardatacenter.mssm.edu), archived before its 2026-06-30 shutdown. Files are byte-identical to the originals (SHA-256 verified). Original deposit DOI(s): n/a.

Tags

Environmental epidemiologyHHEARexposomeenvironmental health1-hydroxynaphthalene1-hydroxyphenanthrene1-hydroxypyrene2,4-Dichlorophenoxyacetic acid2-hydroxyfluorene2-hydroxynaphthalene+4

Licenses

CC BY 4.0

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