The main purpose of this study was to examine the effectiveness of ICT integration on effective teaching and learning process in public secondary schools found in Misungwi district. The study employed mixed research approach and the convergent parallel design for data collection. The study targeted 8087 respondents which comprised 7760 students, 24 school heads, 300 secondary school teachers and 3 district education officers and used 100 respondents as a sample size. The study employed simple random, stratified and purposive sampling to select respondents and the data collection tools were questionnaires, interview and observation. The study revealed that implementation of ICT has many influences on effective teaching and learning process such as it enhances the accessibility of teaching and learning materials, improve teachers and students knowledge and skills and makes lesson more effective, makes student-centered and self-directed, makes and creative good teaching and learning environment, and improve high thinking capacity for students and teachers. The study recommended that ICT infrastructures such as computers and other ICT resources should be adequately provided, and secondary schools leaders should establish income generating projects to increase sources of funds, in-service training to teachers must be provided, as well as special programs on ICT should be provided to boost teachers experience and familiarity on the use of ICT in teaching and learning process.