The importance of cognitive ergonomics, which optimises mental workload and task design, in relation to workplace productivity and health is becoming more widely acknowledged. Cognitive ergonomics interventions have been shown to improve worker well-being and reduce cognitive strain in high-income countries; however, their applicability in African workplaces, where workers frequently face high job demands, resource constraints, and rapid technological transitions, is less well established. This systematic review aimed to synthesise evidence on workplace cognitive ergonomics interventions implemented in African countries, with a focus on their effects on cognitive strain and worker well-being. A systematic search of PubMed, Scopus, Web of Science, and grey literature was conducted up to August 2025. Eligible studies included adult working populations in African settings that reported interventions with cognitive ergonomics or mental workload management components, and outcomes related to cognitive strain (e.g., mental workload, fatigue, burnout) and/or well-being (e.g., stress, job satisfaction, engagement). Screening, data extraction, and quality appraisal were performed independently by two reviewers. Of 312 records screened, six studies met the inclusion criteria. Interventions included workplace cognitive-behavioural training, return-to-work task redesign, organisational well-being programmes, and stress-management workshops. Reported outcomes showed consistent reductions in stress and improvements in engagement, resilience, and quality of life. However, few studies directly measured cognitive workload, and methodological quality varied. Most relied on self-report measures; only limited evidence incorporated objective or physiological workload indicators. Interventions in cognitive ergonomics in African workplaces have been shown to have positive effects on employee well-being and are likely to lessen cognitive strain. With flaws in industry diversity, rigorous measurement, and strong trial designs, the evidence is still in its early stages. To bolster the body of data supporting occupational health policy and practice in Africa, future studies should give special attention to culturally appropriate, multimodal therapies and thorough evaluation techniques.