Diagnosing childhood illnesses can often be challenging, particularly with conditions that share overlapping symptoms. This case report examines the role
of MedBrain, a Clinical Decision Support System (CDSS), in diagnosing common childhood illnesses. The report discusses two clinical cases involving a
9-year-old child diagnosed with chickenpox and a 4-year-old child diagnosed with measles, both in Nigeria. For each case, MedBrain provided a differential
diagnosis with a ranked list of diseases and associated diagnostic scores based on the system's algorithms. The predicted diagnoses were evaluated and
validated by paediatricians, demonstrating the diagnostic clinical utility of MedBrain. This case report offered valuable insights into MedBrain's functionality,
clinical relevance, and potential in clinical research, with the capability to improve diagnostic accuracy in paediatric care.