This study examined the effect of entrepreneurial support systems on the performance of agro-allied small and medium enterprises (SMEs) in North Central Nigeria. Adopting a quantitative research approach, the study investigated the relationship between entrepreneurial support systems and SME performance using primary data collected through structured questionnaires administered to SME operators and employees. The study covered Benue, Kogi, Kwara, Nasarawa, Plateau, Niger States, and the Federal Capital Territory, a region critical to Nigeria’s agricultural value chain. A descriptive survey design was employed, enabling the use of both descriptive and inferential statistics. From a population of 1,492 registered agro-allied SMEs, a sample size of 956 respondents was determined on a state by state basis using Cochran’s formula and selected through simple random sampling. Data were analysed using regression techniques, with variables measured on a five-point Likert scale. Findings revealed that entrepreneurial support systems exert a statistically significant negative effect on SME performance (B = -0.550, p < .001; β = -0.541), indicating that increased engagement with existing support mechanisms is associated with reduced performance. This suggests inefficiencies, poor coordination, or administrative burdens within current support structures, which may constrain rather than enhance SME outcomes. The study recommends that SME operators adopt a strategic approach to engaging with support institutions, aligning participation with specific business goals. It further highlights the need for policymakers and support providers to redesign interventions to be more context-specific, collaborative, and value-chain oriented to effectively enhance SME performance.