Nigeria can accelerate reductions in diarrheal morbidity and deaths by combining high-coverage clinical case management with durable, risk-targeted public health action. At facility and community levels, rapid dehydration assessment, routine oral rehydration solution (ORS) plus zinc for childhood diarrhea, continued feeding, and timely referral for intravenous fluids in severe cases remain the most dependable mortality-reduction package. Yet these gains will be fragile without sustained water, sanitation and hygiene (WASH) investments: safe and consistently treated water, protected sources, functional sanitation, and handwashing with soap, backed by long-term financing, maintenance systems, and behavior change that outlasts short campaigns. Because diarrheal incidence often rises during rains and flooding, hotspot strategies that intensify pre–rainy season preparedness can blunt predictable seasonal surges. Vaccination strengthens prevention: rotavirus vaccine reduces severe pediatric gastroenteritis and admissions, while oral cholera vaccine supports outbreak control and preventive use in high-risk and displacement settings. Strengthened surveillance and preparedness early warning, environmental monitoring, flood forecasting, pre-positioned supplies, rapid response teams, and clear risk communication—enable faster containment. Research priorities include state-level pathogen attribution, rainfall-linked seasonality mapping, antimicrobial resistance tracking (especially Shigella), and evaluation of integrated WASH-plus-vaccine packages targeting inequities.
Keywords: Nigeria, diarrhea, epidemiology, cholera, rotavirus, WASH, seasonality, surveillance, under-five mortality.