This workbook contains the raw deidentified data collected for the PATH study on the costs and operational context of delivering a single-dose human papillomavirus (HPV) vaccine regimen to a multi-age cohort (MAC) of adolescents in four selected regions of Ethiopia. The MAC campaign evaluated occurred in November 2024. This was a retrospective cross-sectional study. Data collection occurred during a three-week period in January and February 2025. A peer-reviewed manuscript based on these data is under review in Vaccine journal. The manuscript is titled "Evaluating the delivery costs and operational context of a single-dose human papillomavirus (HPV) vaccine regimen administered to a multi-age cohort of adolescent girls in Ethiopia" with authors Mercy Mvundura, Rose Slavkovsky, Belayneh Dagnew, Alemayehu Hunduma, Melkamu Ayalew, and Diriba Bedada.