Critical thinking distinguishes students who genuinely understand chemistry from those who merely
memorize facts, yet most instructional approaches fail to cultivate analytical skills in technical education
contexts. Here we address the missing evidence on whether structured prediction-observation sequences
can systematically build critical thinking capacities in acid-base chemistry. In a quasi-experimental
study with 147 Nigerian technical college students, we demonstrate that Predict-Observe-Explain
activities produce significantly larger gains in critical thinking compared to conventional instruction.
Students in the POE group improved from 11.57 (SD = 3.31) to 20.92 (SD = 3.69) on a 75-point
assessment, while controls improved from 11.73 (SD = 3.24) to only 15.82 (SD = 3.18). The group
difference at posttest was statistically significant (p < .001) with a large effect size (Cohen's d = 1.24).
Low achievers derived the greatest benefit, gaining 5.67 points more than their control group
counterparts. Quality of POE engagement strongly predicted practical problem-solving performance
(partial r = .59, p < .001) after controlling for prior ability. These findings establish that critical
thinking can be systematically taught through cognitive conflict generated by prediction-observation
discrepancies. For technical schools preparing students for laboratory careers, this work provides an
accessible, resource-appropriate strategy for developing the analytical competence that industry
demands.