Using exergy and exergo-economic techniques, this paper investigates the rate of exergy destruction of a 180MW gas turbine in the Niger Delta (Nigeria). The method entailed simplifying the plant components into control volumes and analyzing each flow using exergy, economic, and exergy cost principles. The combustion chamber had the highest efficiency destruction (79.15 percent) at 114.55MW, while the turbine had the lowest at 15.01MW (10.46 percent). The air compressor has the highest capital investment, operation, and maintenance costs (240.59 $/h), as well as the highest exergo-economic factor (67.78 percent). Lowering the pressure ratio and/or compressor isentropic efficiency can lower the plant's overall cost effectiveness. Exergy destruction in the combustion chamber can be significantly reduced by increasing the turbine inlet temperature or introducing a pre-heater after the compression process. The overall exergy efficiency was 28.28%, with the first law efficiency at 32.27%.