Logo Lanfrica
  • Accueil
  • Atlas
  • Analyses
  • Documentation
  • Sign in

© 2026 Lanfrica. Tous droits réservés. Tous les droits d'auteur des ressources affichées sur le site Web Lanfrica appartiennent aux détenteurs de droits d'auteur d'origine, sauf indication contraire explicite.

Genetic Characteristics, Coreceptor Usage Potential and Evolution of Nigerian HIV-1 Subtype G and CRF02_AG Isolates

Domaine:

healthcare

Type de record:

dataset
Créateur:
HanMicTulTar
Hôte:avatar

HIV-1 CRF02_AG and subtype G (HIV-1G) account for most HIV infections in Nigeria, but their evolutionary trends have not been well documented. To better elucidate the dynamics of the epidemic in Nigeria we characterised the gag and env genes of North-Central Nigerian HIV-1 isolates from pregnant women. Of 28 samples sequenced in both genes, the predominant clades were CRF02_AG (39%) and HIV-1G (32%). Higher predicted proportion of CXCR4-tropic (X4) HIV-1G isolates was noted compared to CRF02_AG (p = 0.007, Fisher's exact test). Phylogenetic and Bayesian analysis conducted on our sequences and all the dated available Nigerian sequences on the Los Alamos data base showed that CRF02_AG and HIV-1G entered into Nigeria through multiple entries, with presence of HIV-1G dating back to early 1980s. This study underlines the genetic complexity of the HIV-1 epidemic in Nigeria, possible subtype-specific differences in co-receptor usage, and the evolutionary trends of the predominant HIV-1 strains in Nigeria, which may have implications for the design of biomedical interventions and better understanding of the epidemic.

Visit

figshare.com

Tags

BiotechnologyBiological SciencesMathematicsCancercoreceptorusagenigerianhiv-1subtypecrf02_ag+1

Licenses

CC BY 4.0

Similaires

Additional file 1 of Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AGPrediction of Coreceptor Tropism in HIV-1 Subtype C in BotswanaPredicted HIV-1 coreceptor usage among Kenya patients shows a high tendency for subtype d to be cxcr4 tropicRobust Supervised and Unsupervised Statistical Learning for HIV Type 1 Coreceptor Usage AnalysisDrug Resistance and Coreceptor Usage in HIV Type 1 Subtype C-Infected Children Initiating or Failing Highly Active Antiretroviral Therapy in South AfricaHIV-1 DNA sequence diversity and evolution during acute subtype C infection

Additional file 1 of Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG

Supplementary Material 1: Table S1.Panel of 50 subtype G Envs and 18 CRF02_AG Envs from Nigeria. The

Prediction of Coreceptor Tropism in HIV-1 Subtype C in Botswana

It remains unknown whether the C-C motif chemokine receptor type 5 (CCR5) coreceptor is still the pr

Predicted HIV-1 coreceptor usage among Kenya patients shows a high tendency for subtype d to be cxcr4 tropic

Abstract Background CCR5 antagonists have clinically been approved for prevention or treatment of

Robust Supervised and Unsupervised Statistical Learning for HIV Type 1 Coreceptor Usage Analysis

Human immunodeficiency virus type 1 (HIV-1) isolates differ in their use of coreceptors to enter tar

Drug Resistance and Coreceptor Usage in HIV Type 1 Subtype C-Infected Children Initiating or Failing Highly Active Antiretroviral Therapy in South Africa

HIV-1 drug resistance monitoring in resource-poor settings is crucial due to limited drug alternativ

HIV-1 DNA sequence diversity and evolution during acute subtype C infection

Abstract Little is known about the genotypic make-up of HIV-1 DNA genomes during the earliest stage