cgreene3/dynamic_transmission_model_HIV_TB_KZN_SA

A Dynamic Transmission Model of TB and HIV: Quantifying the Impact of Increased Access to Care in KwaZulu-Natal South Africa ## Preventing tuberculosis with community-based antiretroviral therapy (ART) and tuberculosis preventive therapy (TPT) care in Kwazulu-Natal, South Africa: a dynamic transmission modeling analysis The details for the model are provided in the appendix. The description of what is included the repository is provided below. #### This work is available as a pre-print Ross, J.M., Greene, C., Bayer, C., Dowdy, D., van Heerden, A., Heitner, J., Rao, D.W., Roberts, D.A., Shapiro, A.E., Zabinsky, Z.B. and Barnabas, R.V., 2023. Preventing tuberculosis with community-based care in an HIV-endemic setting: a modeling analysis. medRxiv, pp.2023-08. ### Contents in the repository: 1. About the Model 2. Description of Parameter Files 3. Descriptions of Model Execution Files 4. Description of Results Files #### About the Model This repository contains the files needed to execute a dynamic transmission model for tuberculosis (TB) and human immunodeficiency virus (HIV) disease progression that is compartmentalized by TB stage, HIV stage, TB and HIV treatment status, TB drug resistance status, and gender. The model is set up to evaluate the impacts of increased uptake of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT) observed in the community-based intervention of the Delivery Optimization for Antiretroviral Therapy (DO ART) trial, compared to standard, facility-based ART and IPT care. The model projects health outcomes, including TB incidence, TB mortality, TB and HIV prevalence. **TB Transitions** **HIV Transitions** Above is an illustration of the rates of flow for the TB and HIV dynamic transmission model. Rates of flow between each compartment are governed by differential equations, as described in the appendix. Although not visualized here, each TB and HIV compartment is stratified across two TB drug-resistance categories, and two genders. The latent TB infection (LTBI) compartment is distinguished by those infected within two years, considered rec …