GP2code/PD-GeneticCharacterization-inAFRandAAC

This is the online repository for the manuscript titled "Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations" # Large-scale Genetic Characterization of Parkinson’s disease in the African and African admixed Populations `GP2 ❤️ Open Science 😍` **Last Updated:** December 2024 ## Summary This repository contains all analyses for the manuscript titled ***"Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations"***. This study represents the largest sequencing-based characterization of potentially disease-causing protein-altering and splicing mutations in 710 cases and 11,827 controls from genetically predicted African or African admixed populations. --- ### Data Statement * Results were generated using - GP2 data release 8 (controlled-tier access; DOI 10.5281/zenodo.13755496) - All of Us (AoU) genomic data release 7 (controlled-tier access) ### Datasets | Dataset | Release / Version | Resource URL | Notes | |-----------|-------------------|-----------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------| | All of Us | Release 7 | allofus.nih.gov workbench.researchallofus.o… | Controlled-tier data used in this study | | GP2 | Release 8 | gp2.org | Access-controlled data used in this study | | BLAACPD | . | blaacpd.org | Cohort focusing on African / African admixed populations with PD | --- ### Repository Orientation ``` analyses/ ├── 00_Annotation_AFR_PDexome.ipynb ├── …